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Minimizing risk of endotoxin stacking and vaccination-related stress in cattle

Posted on January 20, 2026

Source: Farm Progress. The original article is posted here.

Minimizing risk of endotoxin stacking and vaccination-related stress in cattle
Protecting cattle from Bovine Respiratory Disease (BRD) is essential for maintaining herd health and ensuring operational profitability. However, the use of multiple gram-negative vaccines simultaneously can result in "endotoxin stacking," which contributes to vaccination-related stress in cattle. Dr. Jeremi Wurtz, Beef Cattle Technical Consultant for Elanco Animal Health, discusses how low-endotoxin vaccines can help reduce vaccine stress while effectively protecting cattle from BRD. This approach not only supports cattle health but also optimizes immune response and minimizes risks associated with high endotoxin loads.
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